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Before medicines are approved, they must go through several clinical studies in which thousands of people are given a particular medicine and are then compared to a group of people who were not given the medicine (these people took a sugar pill, or placebo). In these studies, side effects are always documented. As a result, it is possible to see which side effects occur, how often they appear, and how they compare to the group not taking the medicine. Side effects are then usually separated into those side effects that occur in more than 1 percent of people (common side effects) and those that occur in less than 1 percent of people (rare side effects).

Headaches (including migraines) were reported in up to 10.3 percent of adults taking Allegra once a day for allergies. Up to 7.2 percent of people taking a placebo reported a headache. These studies did not separate migraine headaches from other types of headaches.

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